Sentence examples for more focal complexes from inspiring English sources

Cells cultured on test surfaces followed contact guidance along the length of groove edges, elongated along their major axis and showed nuclear distortion; they formed more focal complexes and lower proportions of mature adhesions relative to planar controls.

Additionally, cells cultured under test conditions developed more focal complexes (FX); adhesions associated with cellular motility and cells cultured on 240 nm grooves developed significantly less SMAs.

They develop from smaller and more numerous focal complexes under the influence of mechanical force and are key elements for many physiological and disease-related processes, including wound healing and metastasis.

When α-actinin-1 is incorporated into these adhesions, a more mature focal complex is formed that aids the generation of force necessary for spreading and subsequent migration (von Wichert et al, 2003).

The time scale of the knockdown remains the same, however, although the mRNA gets diminished by almost 80%, the amount of focal adhesions (ACI#) only gets reduced by about 70%, which again indicates that focal adhesions are more stable than focal complexes.

Instead, paxillin staining is found to be more diffuse perhaps associating with immature focal complexes [ 39].

In most cell types, migration-related adhesive structures are composed of integrin heterodimers and intracellular associated proteins clustered in plaques termed focal complexes and their more mature variant, focal adhesions [3].

Cells cultured on planar controls showed a near uniformly spread morphology with significantly fewer focal complexes (associated with cellular spread) and more mature adhesions than on grooved substrates.

The disassembly rate constant of the focal adhesions is assumed to be the mean of the disassembly rates constants for the focal complexes multiplied by a factor ε, which describes how much more stable focal adhesions are compared to focal complexes.

A sensitivity analysis predicts that knockdown of focal adhesion components is more efficient for focal adhesions with slip bonds or if the system is in a state dominated by focal complexes.

In the kinetic model, this important effect is represented by back reactions; for a more detailed model, one would have to introduce reservoirs channeling material from decaying focal adhesions back to growing focal complexes.