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The ligand exhibited a more flexible conformation consisting mainly of a mixture of coil and turn.
Further analysis of RsmH by small-angle X-ray scattering (SAXS) also revealed the dimer in solution, but with a more flexible conformation than that in crystal, likely resulting from the absence of the substrate.
By contrast the small AVP-induced stimulation of receptor is completely inhibited by inverse agonist suggesting that the receptors can also adopt a second more flexible conformation.
JP2 also binds PtdIns 3,4,5) P3 at a different site than PS, resulting in the protein adopting a more flexible conformation; this interaction is modulated by both Ca2+ and Mg2+ ions.
Keto-MA tended more towards a W-shaped configuration with exceptional rigidity in monolayers, whereas methoxy- and alpha-MA exhibited a more flexible conformation towards variation of experimental parameters (Villeneuve et al., 2005, 2007).
These irregular interactions may confer a more flexible conformation of the CC subdomain compared with regular coiled coils such as the leucine zipper, which is stabilized by regular non-polar interactions between two intertwined helices.
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From the molecular dynamics simulation analysis, we confirmed that due to occurrence of mutation the structure loss stability and became more flexible in conformation [ 74].
The structures show how the kinase domain, in the absence of the rigidifying interdomain interactions of the inactivation state, adopts a more open and flexible conformation.
Both JP2 and JP21 452 adopt a more extended and flexible conformation in the presence of PtdIns 3,4,5) PtdIns 3,4,5
In acidic solutions (pH below 5), lactoferrin eagerly adopts more flexible and open conformation, which facilitates the release of ferric ion [ 7, 43].
The analysis showed that in GlcNAc-O-methyl (OMe), GlcNAc-p53, GlcNAc-Histone H3 and GlcNAc-TAB1 the ring adopts conformations between S3 and B. In GlcNAc-c-Myc, the sugar ring adopts an H5 conformation, while in GlcNAc-poly-Ala′ the ring is more flexible, adopting two conformations H3 (45%) and S3 to B (55%).
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