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The R183D mutant was also about 10-fold less active than wild-type enzyme (compare Figures 1A and 1C), suggesting that increased catalytic activity may be an evolutionary advantage of BtMinpp's more flexible active site.
Compared with the ES-1, the ESBC with the proposed control scheme provides more flexible active power compensation capability within the same range of ES voltage magnitude.
Despite the importance of Src as a drug target, there is relatively little structural information available regarding the presumably more flexible active forms.
The absence of the 30 internal amino acids in Ec_ydjA, which forms two helices and restricts the cofactor and substrate binding in other NTR family members, creates a wider and more flexible active site.
Similarly, ADAM17 has been shown to have a more flexible active site than MMP-2 upon binding to a non-competitive inhibitor [ 45].
The central helix α4 of eight amino acids and adjacent flexible loop in ChsH2N generates an even more flexible active site with a larger pocket.
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Here, H-bonding and stacking forces will be weaker, presumably resulting in a more flexible active-site ternary complex.
R pairing of TA, although correct pairwise, provides less stabilizing interaction energy from pairing to the overall complex, resulting in a more flexible active-site complex that produces two distinct LFER correlations that are similar to the W mispairing of GT.
Crinoid, any marine invertebrate of the class Crinoidea (phylum Echinodermata) usually possessing a somewhat cup-shaped body and five or more flexible and active arms.
But their governments have made their labour markets more flexible, with active policies to help the jobless find work sooner.The Dutch model is neither perfect nor painless: it requires stiff wage restraint and lower unemployment benefits.
Molecular dynamics simulations should always be performed to get a more flexible and active state of GPCRs.
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