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Sagopilone also has a more favourable toxicity profile than other tubulin-active drugs.
However, oxaliplatin may offer a more favourable toxicity profile and higher activity compared to cisplatin.
Cetuximab or TKIs plus radiotherapy have a more favourable toxicity profile when compared to chemoradiotherapy.
Attempts have therefore continued to develop MMPIs with a more favourable toxicity profile than currently available agents.
They found superior survival of 3 months and a more favourable toxicity profile for the VG combination.
Clinical studies may still prove whether IDR, ACR or MIT has a more favourable toxicity profile than DNR.
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Oxaliplatin may represent an intriguing alternative to cisplatin with at least comparable activity, but a more favourable global toxicity profile.
In the last decade, oxaliplatin (L-OHP), a third-generation platinum derivative, has been found to represent an intriguing alternative to cisplatin, as it shows a comparable activity but a more favourable global toxicity profile (Misset et al, 2000).
The amendment took into account the dose intensity reached with 3-weekly irinotecan plus docetaxel as well as previously published data indicating a more favourable haematological toxicity profile, if both docetaxel and irinotecan were given in weekly schedules (Hainsworth et al, 1998; Murren et al, 2001).
A further dose reduction to 20 Gy can therefore be expected to translate into an even more favourable profile of toxicity (Jones et al, 2001) thus beneficially impacting on the quality of life of the patients.
Crucially, the toxicity was more favourable than for the previous study in which these dose levels were first piloted.
More suggestions(15)
more favourable binding
more pronounced toxicity
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more nicotine toxicity
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more acute toxicity
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more unwanted toxicity
more gastrointestinal toxicity
more local toxicity
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more renal toxicity
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