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Women also had more favourable stage distribution (higher proportion of localised disease).
A reduction in diagnostic interval could contribute towards lower mortality through a more favourable stage distribution and better treatment options.
Women showed more favourable stage distribution which may be related to the increasing use of modern abdominal imaging techniques.
There was a significant change to a more favourable stage distribution during the study period from the prescreening era to the screening era.
We found a more favourable stage distribution for patients with screen detected colorectal cancer compared with those in the control group and the non-attending group (table).
The lower mortality rate in Wigan, if not because of chance, must be because of a more favourable stage distribution, more effective treatment, or a combination of both.
Similar(43)
In summary, we attribute most of the decline of mortality in Yorkshire in the 1990s to a generalised shift towards more favourable stages at diagnosis and earlier treatment.
These findings are well in line with earlier studies showing that there will be a reduction of advanced tumour stages and increase of more favourable low stage tumours after several years of ongoing screening (McCann et al, 1998).
These results provide evidence for improved survival from colonoscopic surveillance in IBD patients by detecting CRC at a more favourable tumour stage.
There could also be a reduction in advanced-stage tumours and an increase of more favourable low-stage tumours after several years of ongoing screening (McCann et al, 1998; Buiatti et al, 2003).
In conclusion, the patients in the surveillance group showed statistically significant lower CRC-related mortality and more favourable tumour stages.
More suggestions(16)
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com