We considered whether changes in the selection of patients for transplant over the period of the study might have resulted in a non-transplant group with more favourable survival.
Similar at baseline is also the percentage of brain, bone and liver metastatic sites, whereas more favourable patient selection resulted because of nephrectomy, normally present in 80 90% of treated patients, that was a mandatory inclusion criteria in the TIVO-1, as in the AVOREN study.
In conclusion, lipid traits are both more variable and exhibit more favourable genetic architecture for selection compared to protein traits.
Only a fraction of such populations probably sought more favourable conditions elsewhere, but natural selection favoured the "migrants," and migratory tendencies were retained.
It is more likely to reflect the selection of more favourable, better motivated women and technically 'less challenging' polyps to surgically remove in the office setting by the operating surgeon.
At these stages, the most effective strategy for a developability risk assessment would largely rely on the use of computational tools to categorise or flag (ideally automatically) high-risk candidates to help guide the selection of more favourable molecules to be taken into later stages of development.
Prognostic variables identified by LCM define a HER2-positive MBC profile profile and therapies that may be associated with more favourable long-term outcomes, enabling treatment selection appropriate to the patient's disease characteristics.
We acknowledge a number of limitations of our study: it is a single-arm trial with a high likelihood of selection bias in favour of patients with more favourable tumour biology.
Industry sponsorship is discussed as being associated with the following factors: selection of inappropriate comparators, selective reporting of more favourable per protocol analyses, pro-industry conclusions, as well as restrictions on publication and data sharing [ 63- 65].
China should have used the visit as an "opportunity" to explain why its policy on the selection of candidates was more favourable, he reasoned.
