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This would shift the cellular patterns to the more favourable prognostic category.
Overall, screen detected cancers tended to show more favourable prognostic features across the various molecular categories.
In the phase III vinflunine trial, patients who had received prior cisplatin had overall more favourable prognostic criteria (Table 1).
We observed more favourable prognostic factors and survival outcomes in women with screen detected breast cancers compared with symptomatic patients.
Secondly, the outcomes of multidisciplinary care could have indicated selection biases towards patients with more favourable prognostic features rather than true treatment effects.
This suggests more favourable prognostic features of the patients in the Taiwan study, which may also have increased the probability of tumour response.
Similar(46)
Low expression of calpain-9 was associated with patients over 40 years of age (P = 0.025), smaller tumour size (P = 0.001), lower tumour stage (P = 0.009), a more favourable Nottingham Prognostic Index value (P = 0.002) and positive oestrogen receptor status (P = 0.014).
MSI-high tumours generally have a more favourable prognosis relative to MSS/MSI-low tumours, independent of stage, grade, and other prognostic variables (Guastadisegni et al, 2010).
Although it was argued that Adjuvant! provides a more individual prognostic assessment, this scoring system does not take into account the method of detection and the fact that screen-detected tumours generally have a more favourable prognosis.
It thus appears that intensive chemotherapy is likely to be more effective when favourable prognostic features are recorded.
Furthermore, the series that presented response and survival data superior to those reported here included more patients with favourable prognostic factors (younger age, better PS) or had many patients who had been treated with chemotherapy alone.
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