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Although it seems reasonable to assume more favourable outcomes when PK/PD is optimised, clinical outcome data favouring continuous infusion are far from conclusive.
Extensive evidence shows that industry-funded trials systematically produce more favourable outcomes than non-industry sponsored ones," they write.
Guidelines suggest more favourable outcomes when used in patients with chronic obstructive pulmonary disease (COPD) and cardiogenic pulmonary oedema (CPO)[1], yet its use often extends beyond these indications despite no evidence of clear benefit.
Pregnancies presenting at earlier gestations had more favourable outcomes on repeat scans.
The pCR group had more favourable outcomes, despite this population having a higher Ki67 proliferation rate.
Secondly, it would be difficult to imagine more favourable outcomes than those achieved in this trial.
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In the example of a new drug, it may be that participants with certain characteristics have a more favourable outcome irrespective of drug treatment.
Martin Haworth, the union's director general, said: "Some of the scenarios appear to suggest that there could be serious risks to farm income from leaving the EU, while the results of others suggest there could be a more favourable outcome.
Following the natural history and the implementation of standardised non-operative treatment programmes of shoulder dislocation results in a more favourable outcome than surgical intervention in many cases.
Heterotypic transplantation into neurogenic regions such as DG may have a more favourable outcome, though this remains to be firmly established.
Thus, early detection by newborn screening (NBS) is absolutely essential for achieving a more favourable outcome and indeed, disease mortality and morbidity is significantly reduced [2], [3].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com