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Second, more extreme ratios emerge.
Interestingly, this shift in ratios contrasts the general trend showing more extreme ratios for the probes not affected by the T7 bias in amplified RNA data.
However, the ORs are only modestly different from one, 0.75 at the most extreme, so that biases are a more plausible explanation than they would be with more extreme ratios.
However, gamma correction yielded a much higher frequency of accurate reconstructions, with the uniform prior performing better than the exponential prior at the more extreme ratios (Wilcoxon P ≤ 0.003906 at 70-fold) as judged by symmetric distance.
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Accuracy is diminished at more extreme viscosity ratios when the less viscous fluid is in a thin layer.
That is, males did not tend to have more extreme digit ratios than females when compared strain-by-strain.
Xie et al. [19] carried out TDT testing in that subgroup, obtaining slightly more extreme odds ratios (but wider confidence intervals) in the smaller dataset.
Genes with more extreme imbalanced ratios tend to have lower read depth, which decreases precision of measuring allele specific expression.
More extreme allelic ratios are considered to be homozygous, appearing in the dataset due to sequencing errors.
Any SNP locus with a more extreme allelic ratio is considered homozygous and assigned the color corresponding to the homolog with the matching allele in the map.
The proportion of such null gene groups with a sign sum as extreme as, or more extreme than, the ratio sum of the real regulon was taken to be the nominal empirical P for directional expression divergence.
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