Future simulations for more extreme parameters than those explored by Christensen and Aubert (2006) will further clarify the applicability of the proposed scaling law.
The lowest rejection rate was observed when matrices obtained from nucleotide sequences simulated under more extreme parameters of evolution (i.e., s = 0.02; α = 0.06) were tested.
However the realization of increasingly high degrees of MFMS requires more and more extreme choices of parameters and increasing cross-regulation.
Given the fact that some selected parameter values were on an unexplored border of the parameter grid, we studied whether more extreme values for the border parameters led to better results (and continuing if deviance was within the second step best deviance +5%).
The linear extrapolation model is supported from more extreme ("worst-case") toxicological parameters, which suggest a low-dose linear relationship for the carcinogenic effect in the scientifically non-accessible part of the exposure response curve, which neither can be ruled out nor can be supported experimentally.
The proportion of simulated H or D parameters with more extreme values than those observed corresponds to the hypothesis test p-value.
Finally, the P-value of the observed slope parameter is obtained as the fraction of replicates that are more extreme than or equal to the observed slope parameter.
A short diffusion range enables a mixed equilibrium (coexistence of +/+ and −/− cells) for a larger set of parameters (higher c and more extreme h values).
This model misspecification for ML leads to in incorrect inference of parameters, which is even more extreme for long branches [ 18] (this justifies the bad performance of ML in the lower right corner of Figure 1(b)).
Climate change is a change in the long-term average value of a particular climate parameter, including both more variability and more extreme weather events.
