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Finally, many Fox2 targets are in turn splicing regulators, suggesting the existence of more extensive splicing networks [ 38].
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While this is not certain to cover the full spectrum of all possible splice variants in all tissues, it highlights the fact that more extensive alternative splicing does take place and will affect conclusions made without knowledge of isoform architecture.
"It may be that the fly makes more extensive use of alternative splicing," said Dr. John Sulston, a leading worm person at the Sanger Center in England.
Gene model in AceView provides more extensive analysis of alternative splicing.
A more extensive analysis of echinoderm splice sites has not been completed previously because, prior to the availability of the assembled S. purpuratus genome, insufficient numbers of gene sequences were available to analyze.
This result also indicated that XBP1 splicing was more closely associated with apoptosis induction than activation of ATF4, since a low dosage of proteasome inhibitor (5 nM, 15 h) that was sufficient to stimulate activation of the ATF4 and CHOP reporters (Fig. 9C) was incapable of eliciting XBP1-splicing and more extensive apoptosis (compare also with Fig. 1).
We are aware that RNA-Seq enables a more extensive profiling of the transcriptome by facilitating the discovery of fusion genes [ 20], detection and quantification of alternative splice forms, and characterization of expressed mutations and polymorphisms [ 14].
French influence was more extensive.
"This is much more extensive".
(Drop-off locations are more extensive).
It will be a more extensive procedure.
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