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Overall, the 147 patients in the COPD group were older and more likely to be male, and to have a more extensive smoking history, as compared with the 123 patients in the non-COPD group.
In this study, among the HPV DNA-positive subgroup, patients with tumors negative for p16 expression had a significantly more extensive smoking history than those with tumors positive for p16 (P < 0.001, Student's two-tailed t-test), suggesting that heavy smoking might be responsible, at least in part, for DNA methylation at the p16 gene promoter and a consequent loss of p16 expression.
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It is necessary to maintain and intensify the campaigns against prenatal SHS using communication media, more extensive and severe implementation of smoke-free legislation and educational actions in favour of decreasing the smoking habit among pregnant women.
This review does not include trials in which smoking cessation was a part of a more extensive complex intervention and in which only a proportion of patients had diabetes and smoked at baseline.
Emphysema was more extensive in NSIP patients than in group B healthy smoking control subjects (median 0, range 0 18.5), P < 0.0001.
French influence was more extensive.
"This is much more extensive".
It will be a more extensive procedure.
And yet it could be more extensive.
(Drop-off locations are more extensive).
Pike got far more extensive press coverage.
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