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SSc indicates a more extensive skin involvement and even internal organ diseases.
More extensive skin disease was associated with higher prevalence of PsA, which has also been seen in previous studies.
More extensive skin and subcutaneous, joint or visceral tissue injuries in early life also have long-term effects but are not associated with widespread hyposensitivity.
Diffuse symptoms with more extensive skin involvement were present in eight patients (mean disease duration <5 years, total skin thickness score range 27 30).
A patient comes in with a clipping from a magazine that suggests tetracycline is the best treatment for more extensive skin lesions on the central part of their face.
Indeed, SSc subjects with rapidly progressing and/or more extensive skin thickening are more likely to have higher mRSS and be aggressively treated with DMARDs, potentially resulting in a seemingly positive effect of DMARD exposure on the mRSS.
Similar(51)
The higher COMP levels seen in dcSSc are most likely a reflection of more extensive fibrotic skin involvement, as the COMP found in the circulation in SSc patients is thought to be released from the skin.
In general, skin-directed treatments are first-line agents in early-stage disease, and systemic therapy is utilized in patients with more extensive or refractory skin disease or more advanced disease, often in combination with skin-directed treatments.
Some patients with severe disease had previous contact with a specialist (usually a surgeon) as a result of treatment for a previous lesion, or they required more extensive surgery and skin grafting, which general practitioners would not normally perform.
Specifically, more extensive self- and physician-skin examinations focusing on the palms, soles, subungual areas, and the mucosa may be needed for AA in order to diagnose acral melanomas early.
One possible explanation is that GAS skin disease is more extensive in indigenous Fijian communities and that this leads to a higher risk for invasive GAS disease.
More suggestions(15)
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