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The maximum viremia levels we measured in experimentally infected horses were approximately 1,000-fold 1,000-fold titers measured in previous studies using subtype IAB and IC VEEV strains from more extensive outbreaks (4, 6, 7, 9, 25 – 28, 30 ).
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Having a preservative-containing alternative may have averted a more extensive outbreak of disease.
These data suggest that the duration and scope of the recent Mexican epizootics were limited by lack of equine amplification characteristic of previous, more extensive VEE outbreaks.
This led to high confidence in the prevalence estimates, but due to the bias caused by the sampling of certain bird species during the outbreak, more extensive virus circulation cannot be excluded (Figure 5, A).
Had the East and West Coast MenB outbreaks been more extensive, hundreds or even thousands of people could have died or been maimed.
This suggests that MLVA6 could be useful in some epidemiologic settings such as in an outbreak investigation, though more extensive study would be required to confirm this suggestion.
Finally, there was a marked impact of temperature with larger outbreaks (Figure 1) and more extensive spread (Figure 2) for the 2006 compared with the 2007 temperatures.
The A1.a sub-lineage experiment predicts a more extensive geographic distribution than that of the outbreak experiment, including areas in the northern interior and western portions of the country.
The A1.a sub-lineage experiment predicted a more extensive geographic area of anthrax presence than did the outbreak experiment.
Because dengue is a mosquito-borne disease, it necessarily will encompass a wide variety of entities in outbreak management and inclusion of a more extensive group of stakeholders than a disease not involving a vector.
In contrast to historical data, evaluation of algorithms using simulated data allows more extensive evaluation of performance across a large number of datasets with precisely identifiable outbreak and non-outbreak periods.
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