Sentence examples for more extensive mutations from inspiring English sources

Second, more extensive mutations targeting the central appendage either completely disrupted (ΔLQPNP) or reduced (EndoA(Arf -HA) the in vivo function of endophilin-Arf -HA

These more extensive mutations seen after long-term in vivo replication were associated with a change to a tier 2 profile for SHIV-1157ipd3N4.

Thus, the OncoMap platform provided more extensive mutation information than earlier mutation profiling efforts which focused exclusively on oncogene mutations.

More extensive mutation to disrupt both sites further compromised regulation by miR-965.

Of these cases, five were due to the testing having changed (e.g., more extensive mutation analysis now available or a significant change in test analytical methodology) since the original testing performed.

Although we need more extensive analysis, V599E mutations might contribute to tumorigenesis in DNs.

More extensive MMR gene mutation testing to include deeper intronic sequence may yet yield further germline mutations.

However, such an investigation would likely require analysis of Arp2/3 complex mutations and of a more extensive panel of VCA mutations.

Early evidence of epistasis between resistance mechanisms was mostly inferential and anecdotal (Perron et al. 2008a), but more extensive screening of resistance mutations in experimental microcosms has revealed complex interactions between different mutations (Trindade et al. 2009; Ward et al. 2009).

However, using this system and others like it, it will be possible to conduct more extensive genetic screens for mutations that influence compensatory growth or regeneration.

Especially, inactivating mutations in PTPRT warrant more extensive sequencing of the whole PTPRT gene as these mutations, unlike activating mutations in STAT3, do not cluster in hotspots.