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More extensive inflammation may adversely affect CNS function [ 22].
Metabolic differences in fecal profiles were more marked in the CD group, indicating more extensive inflammation in the specific study.
H. pylori strains possessing the cytotoxin-associated gene A (CagA) protein, a well-known virulence factor, cause more extensive inflammation and severe atrophy in gastric mucosa than nonproducers [ 14, 15].
When considering the pathological processes that have been associated with an increase in Cho and Ins [Bitsch et al., 1999; Kirov et al., 2009; Pan et al., 1996], these findings would be compatible with more extensive inflammation with increased membrane turnover [Frischer et al., 2009; Kirov et al., 2009], and greater glial hyperplasia and proliferation in the CST of patients with RRMS.
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Similarly, significantly less radiographic progression was observed in patients with baseline serum levels CRP≤1.5 mg/dl, that is, those with less systemic inflammation, than in patients with more extensive baseline inflammation (CRP>1.5 mg/dl).
2 Alveolar macrophages and the bronchiolar epithelia of normal lungs express integrins, but integrin expression is more extensive during inflammation.
Those with lower hemoglobins, however, had more extensive systemic inflammation as measured by both IL-6 and C-reactive protein levels [ 12].
'Pyelitis' refers to the initial inflammation that is observed secondary to neutrophil influx into the submucosa, the collecting system and the renal pelvis, and 'nephritis' refers to the more extensive renal inflammation that encompasses other tubular segments and the interstitial compartment (Johnson et al., 1992).
For more extensive summary on inflammation in AD and ATH the reader is referred to recent reviews [ 116- 119].
PR3-ANCA is associated with granulomatous inflammation, more extensive extrarenal involvement, and a higher relapse rate.
Furthermore, GK400 rats revealed more extensive and marked infiltrative inflammation, complete destruction of glomerular capillaries, degeneration of the tubules and foamy appearance in the tubular epithelial cells.
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