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Additionally, nuclear Snail protein was associated with more extensive hypoxia, defined by expression of the HIF-1 α-inducible gene CAIX (Chaudary and Hill, 2006), implying a link between hypoxia and EMT in primary breast cancer.
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The results strongly suggest a correlation between the degree of hypoxia - severity and time of exposure - and the number of hemorrhages: many more climbers in Gr2 (93%) - who had had sustained longer and more extensive systemic hypoxia- showed retinal hemorrhages at BC2 than in Gr1 (62%).
In particular patients with a low perfusion pretreatment value showed a statistically significantly higher local failure rate than those with a high perfusion value (P < 0.05), presumably due to a more extensive degree of hypoxia in low-perfused tumour and therefore characterized by low radiosensitivity.
The effect of radiation and chemotherapy can be significantly affected by the tumor microenvironment, thus tumors with extensive hypoxia are more resistant to radiation and some forms of chemotherapy, and poor blood perfusion may reduce the uptake of chemotherapeutic drugs [ 10].
These findings indicate that the transcriptional response to hypoxia is substantially more extensive than previously considered.
Biopsies of invasive cervical carcinomas also showed a good correlation between staining for the two hypoxia markers, CA9 staining being more extensive in almost all cases (Olive et al, 2001).
That is, the more extensive immunostaining for involucrin is due to rapid induction during acute changes in hypoxia that pimonidazole binding cannot match.
French influence was more extensive.
"This is much more extensive".
(Drop-off locations are more extensive).
Pike got far more extensive press coverage.
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