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This allows a more extensive hepatic resection, and reduces the rates of post-operative complications including liver dysfunction [ 29].
If the former, presumably the icterus reflected a more robust immune response to the virus, resulting in more extensive hepatic injury and the development of icterus or jaundice.
This strategy is associated with up to 19%% patient mortality and perioperative morbidity from 14 to 76 %. 3 These higher morbidity and mortality rates are observed as a result of the necessity of more extensive hepatic resection combined with resection of the extrahepatic bile duct.
This could be explained through studies carried on schistosomiasis mansoni-infected B cell-deficient mice, which revealed more extensive hepatic granulomas that were explained by the role of B-cells in the down modulation of liver pathology through promoting Th2-type responses [ 31, 32].
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Liver ablation in patients with more extensive extra-hepatic disease is of uncertain value.
Inferior vena cava (IVC) involvement can often be dealt with by simple venous side-clamping or in more extensive cases by total hepatic vascular isolation with IVC clamping and the selective use of a veno-venous bypass.
The more extensive investigations about the cells contributing to hepatic fibrogenesis have focused on hepatic stellate cells (HSCs) and myofibroblasts (MFs).
Moreover, obese patients are likely to be more sensitive to sepsis [ 4- 6], possibly due to the presence of hepatic steatosis or the more extensive pathology known as non-alcoholic steatohepatitis, a condition involving steatosis, inflammation, necrosis and may also include some degree of fibrosis.
After an overdose, glucuronidation and sulfation routes become saturated and more extensive bioactivation of APAP occurs, leading to rapid depletion of the hepatic GSH pool.
Patients with isolated hepatic metastases have a better prognosis than those with more extensive metastatic disease (Goslin et al, 1982; Lahr et al, 1983; Stangl et al, 1994; Rougier et al, 1995) suggesting biological differences in the two settings (Goslin et al, 1982; Lahr et al, 1983; Stangl et al, 1994; Rougier et al, 1995).
Unlike the GIST population, where liver metastases can be more extensive and are often treated with site-specific therapies, including surgical liver resections and hepatic arterial chemo-embolization, patients with metastatic breast cancer are largely treated with systemic therapies and, as such, have a greater baseline liver reserve.
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