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A definitive conclusion might be achieved by a more extensive dose fractionation study up to 48 h with several different dosing regimens to break the colinearity (44 – 44).
The most promising spiroindolone, KAE609, which is currently in clinical development, was selected for more extensive dose fractionation studies in the P. berghei murine model.
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The glycan receptor binding preference of the H2N2 viruses was characterized using agglutination of red blood cells (RBCs) followed by a more extensive dose-dependent direct glycan array binding assay.
Western blot analysis showed extensive degradation/fragmentation with H2O2 treatment after overnight treatment; therefore a more extensive timecourse and dose response were performed.
In contrast, considering the case of plastic-embedded material, as the electron dose rate appears to be more limiting than total dose, more extensive data acquisitions are possible especially if the dose rate is low.
Spleen and blood cells of animals infected with the highest dose gave rise to more extensive proliferation compared to lower dose inoculation (Figure 3B).
Consistent with their more extensive DNA substitution, a dose of 1 kJ m−2 UVA produced 90 and 100% growth inhibition in AY27 cells cultured in 10 and 200 μ STdR (data not shown).
In our cohort 49% of all patients were diagnosed before 1983, in a period in which higher radiation doses and more extensive radiation fields were used.
J. Paul et al. describe an ultrafast cone-beam CT imaging protocol during image-guided hepatic TACE, which reduces the required volume of contrast media and radiation dose, thus allowing more extensive treatment.
The use of the herb is not recommended due to underlying risks of hepatotoxicity and renal failure unless more extensive studies establish safe and effective doses of the alkaloid [15, 73].
That means he can withstand stronger doses of chemotherapy and more extensive surgery than an older patient could.
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