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With more extensive defects, there is controversy whether bone impaction grafting can be used.
In the more extensive defects there is controversy whether bone impaction grafting can be used.
Loss-of-function mutations in Msx1/2 and Dlx1/2 result in much more extensive defects in craniofacial development than the phenotypes observed in the dumbo rat and mouse (Ishii et al., 2005; Qiu et al., 1997; Qiu et al., 1995).
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Dogs from commercial breeders may have more extensive congenital defects -- like heart disease, blood disorders and hip dysplasia -- that may not become apparent for several years, she says.
Although denervation was still absent, more extensive NMJ defects were now evident at PS130, which may also be due to muscle regeneration (Fig 4D).
It was hypothesized that in subjects undergoing MPI for suspected coronary artery disease (CAD), those with diabetes would have more extensive perfusion defects and that diabetes control would influence MPI abnormalities.
In more extensive cases, cortical defects can also be detected (Fig. 8).
The phenotype of both the targeted allele homozygotes and the double heterozygous embryos appears to be slightly more severe than that of hitchhiker homozygotes, with more extensive oedema and defects in eye development.
If a genetic diagnosis is not reached after eliminating common molecular defects, more extensive testing should be carried out.
The defects are typically more extensive in width that in depth.
Unexpectedly, the labrum-only defects observed in the iBeetle screen (i.e. cuticles showing no other defects apart from the labrum; "Only Lr") were not observed in this experiment while overall, the defects were much more extensive.
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