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More detailed analysis of GI tract malformations in Shh−/− mice has revealed more extensive abnormalities: intestinal malrotation, annular pancreas, duodenal stenosis, abnormal gut innervation, and intestinal transformation of stomach [46].
Open surgery for reflux is a treatment choice for high-grade reflux, particularly when the reflux is associated with more extensive abnormalities of the ureter or bladder.
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Mild impairment of attention and concentration may occur in any mental illness where people are anxious and distractible (including psychotic states), but more extensive cognitive abnormalities are likely to indicate a gross disturbance of brain functioning such as delirium, dementia or intoxication.
In a study of 115 patients with acute dyspnea with and without acutely decompensated heart failure, higher levels of galectin-3 were significantly but weakly correlated with Doppler indices of higher filling pressure (E/ e′, r = 0.345) and more extensive diastolic relaxation abnormalities (e′, r = −0.246) [ 56].
In one patient (Patient 3) the increase was in the affected temporal lobe, but was more extensive than the abnormality seen using the modulated images and extended to the posterior part of the temporal lobe resection.
MR abnormalities were more extensive because of surrounding reactive tissue, and more focal TI-201 uptake could be demonstrated within the region of MR signal abnormality, allowing the focal metabolically active tissue to be distinguished from adjacent edema.
Only 3 of these 11 patients also showed uptake on the diagnostic I scan, but the uptake was more clearly visible and the abnormalities were more extensive on the I-PET.
In only three of them (no. 1 3) was the uptake also observed on the diagnostic I scan, but the uptake was clearer and the abnormalities were more extensive on the I-PET scan (Fig. 2).
The abnormalities in bone are more extensive than the physical examination would suggest.
Therefore, they were at later tumor progression stages, where more extensive genomic instability develops and more genomic abnormalities accumulate.
Figure 2 summarises an algorithm for management of atrial arrhythmias.w15 Development of atrial tachycardia is commonly associated with haemodynamic abnormalities which will require more extensive haemodynamic, functional, and metabolic evaluation.
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