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More explicit study of Huntington's Disease is required in order to draw definite conclusions about the benefits of DT in Huntington's.
This suggests that ant farming practices for meat [ 50, 51] deserve more explicit study, as they may provide remarkable insights into sustainable farming practice.
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In the case of identical on and off trial therapies, survival could be influenced by the existence of more explicit on study treatment protocols, more rigid adherence to treatment schedules and follow-up guidelines (Colette et al, 1999).
The theoretical exploration of this – in its very essence group-selectionist – scenario of prebiotic evolution requires a series of chemically more explicit simulation studies, part of which are underway.
More explicit, a recent study hypothesizes that in aging neurons down-regulation of FKBP12 activates mTOR and enhances RyR mediated Ca2+ release [ 5], explaining the Ca2+ signal phenotype typical of aged neurons [ 12].
Making the non-technical skills more explicit in such studies would, in our opinion, enhance patient safety awareness.
Therefore, although the present analysis excluded patients with severe visual impairment, the overall assessment and adjustment for vision within the study is more explicit than that in previous studies.
The NCDS does have a more explicit health focus and study branding and whilst this may increase the consent rate to link to health administrative data (since it is seen as a salient request), it may increase the differences in health between those who are willing to consent and those who withhold it.
Although many articles present case studies, such comparative case analysis would require more explicit use of formal case study analysis approaches than is common.
1) The authors should make more explicit the limitations of the study in the Abstract and conclusions; their current summary creates false expectation.
Methodologically rigorous conclusions would require a much larger study, with more explicit control of variables such as renal function, use of inotropes and baseline-dependent and time-dependent variables (age, gender and admission diagnosis) included in a rigorous multivariable analysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com