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It also marks the departure from a discovery-driven workflow to an inherently hypothesis-driven method that lends itself to explore interactions of a protein of interest in a targeted approach that is more sensitive and that results in larger number of constraints, translating into higher-accuracy models with more experimental support.
More experimental support, such as that provided by Tanikawa et al. (2010), is necessary to clarify this problem.
IAA biosynthesis via the indole-pyruvic acid (IPA) pathway has garnered more experimental support since the characterization of Arabidopsis tryptophan amino transferase 1 (TAA1) gene mutants defective in the conversion of L-tryptophan to IPA (Stepanova, Robertson-Hoyt et al. 2008; Tao, Ferrer et al. Ferrer et al. 2008).
If the authors find this point so important they should provide some more experimental support.
Target sites predicted by more programs and that have more experimental support, i.e. CLIP-Seq, may be more credible.
Taken together, these reports arouse suspicion that light could also influence nitrogen metabolism, but there is clearly more experimental support needed to evaluate this hypothesis.
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Reduced armor is thought to be connected to increased growth rate and lower risk of predation, although this conclusion awaits more solid experimental support.
New data here provide more convincing experimental support that MTs respond to stress, and novel work with an AFM system shows that MT patterns and cellulose MF patterns match.
This conclusion needs more experimental data to support in the future.
The two modified test methods can eliminate or cancel out the effect of histidine in SAA on his+ revertants, and are suitable for evaluating the mutagenicity of Chinese traditional medicines, though need more experimental results to support.
We found that 97.8% of the isoforms had one or more kinds of experimental support (RNA, ORF sequence tags (OSTs) and/or ESTs), described as "confirmed by cDNA s)" or "partially confirmed by cDNA s)", thus only ~2.2% of isoforms are predictions.
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