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Some optimization approaches may take more time than the traditional pilot trial, but the pace of the overall research enterprise will be improved by more quickly discarding or modifying interventions that are unlikely to be found effective in larger and more expensive trials.
Additionally, after the failure of two vaccine trials there is a need to rapidly evaluate vaccine candidates, especially in smaller numbers of individuals before conducting larger and more expensive trials.
Ideally, further studies exploring the optimal package of care for improving oral cleanliness should be undertaken before planning larger more expensive trials that have outcome measures such as VAP, mortality or length of stay.
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The results would establish the doses for much larger, and more expensive, Phase III trials, whose results are at the center of any submission to the F.D.A.
Preventing many cases from going to the crown court for a more expensive jury trial, it has been claimed, would produce significant savings.
Within a year (2001), results of the much larger, longer, and vastly more expensive CAPRICORN trial were published in The Lancet, showing the therapeutic benefits of the proprietary drug, carvedilol, in heart failure.
For the above reasons even if the probabilities under the alternative hypothesis are correctly specified, some trials of high-risk subjects may be more expensive than larger trials of average-risk subjects with the same power and type I error.
Creating a separate offence of causing minor injuries would enable far more offences to be dealt with by magistrates courts rather than more expensive crown court trials.
Tedious and bureaucratic rules may result in more and more incentives being necessary to persuade physicians and their employers to carry out trials, making trials more expensive.
If they help patients enough to get to the less risky, but much more expensive late-stage trial stage, the City will be satisfied that Glaxo's future is a profitable one.
Even if the model is correct (namely p C and p I are correctly chosen), the smaller trial of high-risk subjects may be more expensive than the larger trial of average-risk subjects from the general population.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com