Furthermore, these results suggest a possible neuroendocrine mechanism underlying some of the sex- selective behavioral effects reported in the literature after perinatal CPF exposure, which points to a greater vulnerability of the male sex, more evident in later developmental stages (Aldridge et al. 2005a; Dam et al. 2000; Levin et al. 2001).
These results demonstrated that the functional significance of the transgene is more evident in the older stage than in the early developmental stages.
Children with Alternating Hemiplegia of Childhood are prone to developmental delay, with deficits in cognitive functioning becoming progressively more evident as they grow older.
Children with a rare neurodevelopmental disorder, Alternating Hemiplegia of Childhood (AHC; OMIM: 614820), are prone to developmental delay, with deficits in cognitive functioning becoming progressively more evident as they grow older (Panagiotakaki et al., 2010; Sweney et al., 2009).
It is possible at a subsequent developmental stage characterized by greater lignin biosynthesis that diminished CAD activity would be more evident.
We show here that developmental exposure to CPF affects the constitutive protein levels of OT and AVP, with a more evident effect in males, whereas PRL is unaffected.
Changes in transcript profiles during developmental transitions that included the most extreme time points, Day0 → Day5 and to Day15 → Day25, were more evident and involved a larger number of genes than changes at the intermediate time points, especially Day11 → Day15.
Notably, a reduction of FGF8 mRNA abundance was also seen in the embryonic FLs of Dlx5 Dlx6 DKO embryos, showing no evident developmental defects, suggesting that the down-modulation of FGF8 is not the mere consequence of cell suffering, but more likely a transcriptional misregulation occurring in both the HLs and the FLs.
Some differences are subtle, some more evident.
