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Then some friends advised him to switch to a more established agent.
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Randomized trials have greatly clarified the precise role of the more established of these endocrine agents, but, in addition, a variety of new agents are currently under development.
1) A "guideline" approach that advocates sequential addition of antidiabetes agents with "more established use" (1); this approach more appropriately should be called the "treat to failure" approach, and deficiencies with this approach have been discussed (2).
Other unpalatable options include transforming themselves into agents for bigger, more established players such as Western Union, so the money in effect goes through Western Union's systems.
As agents like ipilimumab becomes more established as an anticancer approach, it will be necessary to weigh the possible benefits of immunotherapy against the time required to confirm disease progression as part of clinical decision making.
This way, newcomers and established agents can be distinguished.
In our data-driven modeling approach we use aggregated network data to calibrate the probabilities at which agents establish collaborations with either newcomers or established agents.
These encouraging results have been obtained with established agents.
Charles Ferrari, the agent marketing the scheme, says: 'Prices are around half that in more established areas like the Tarentaise.
The brand is getting more established.
And for the more established VC funds?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com