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If the rate is adjusted to exclude counting "sequenceable" CpGs in repeat-region DNA, the richness of DMCs in exons and CGIs is still apparent (11.41% and 15.9%), suggesting these regions attract more epigenetic reprogramming in neoplastic cells.
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Identification of the lineage-specific machinery that enables epigenetic changes specifically in the embryo will lead to a more complete understanding of the events underlying normal gastrulation and epigenetic reprogramming.
Epigenetic reprogramming in the germline resets genomic potential and erases epigenetic memory.
Epigenetic reprogramming involves processes that lead to the erasure of epigenetic information.
DNA methylation and histone acetylation are the main modification patterns in epigenetic reprogramming.
The most interesting issue in cloning by nuclear transfer is epigenetic reprogramming.
The mammalian germ line undergoes extensive epigenetic reprogramming during development and gametogenesis.
During germ cell maturation and gametogenesis, cells of the germ line undergo extensive epigenetic reprogramming.
It is thought to be associated with epigenetic reprogramming [ 12].
Cellular differentiation is tightly linked to extensive erasure and establishment of lineage-specific epigenetic marks, a process termed epigenetic reprogramming.
DNA methylation, an important epigenetic reprogramming mechanism, is essential for normal embryonic development.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com