The design of chronic bioassays that incorporate more sensible endpoints than acute tests is discussed to address sediment quality for environmental quality assessment and regulatory proposes.
5. Response is generally a more efficient endpoint than survival for discovering predictive biomarkers, and progression-free survival is also more efficient than overall survival.
This suggests that cholinesterase inhibition is at least a 10-fold more sensitive endpoint than pup mortality for dietary exposures.
Sørensen et al. (2015) concluded mortality to be a more appropriate endpoint than immobility, in order to account for toxicity rather than physical restriction.
Since schistosome eggs are the principal cause of pathology in schistosomiasis, reduction in liver egg may be a more meaningful endpoint than adult worm burdens.
Thus, it may be possible to improve our etiological insight in particular risk factors when a more specific endpoint than "RCC" can be defined, e.g. based on histology and mutational status of a gene involved in tumor carcinogenesis.
As noted above, survival has the advantage of being a more precise endpoint than response, but it has the distinct disadvantages of being impacted by a variety of factors unrelated to therapy efficacy, one cannot tell which patients actually benefited from therapy, and it requires several months or years of patient follow-up time.
Different authors explored more appropriate and richer toxicity endpoints than DLT.
Biological effectiveness of ionizing radiation differs with its linear energy transfer (LET) such that high-LET radiation is more effective for various biological endpoints than low-LET radiation.
Further, rather than being restricted to BMI like many previous studies investigating the relationship between adiposity and dementia, HIMS collected information on three key-markers of adiposity, two of which are considered good indicators of central obesity and are more strongly associated with cardiovascular endpoints than BMI [25], [26].
