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We explored all nine cancer sites for which two or more eligible studies were found.
The reference lists of included reviews were also screened to find more eligible studies.
Funnel plots will be used to assess publication bias if we identify 10 or more eligible studies.
Besides, the manual search was performed to retrieve some more eligible studies in the reviews and references of included studies.
Symmetry of funnel plots will be used to assess for publication or selective reporting bias if we identify 10 or more eligible studies.
Although three recent reviews addressed somewhat similar questions, our meta-analysis identified and included more eligible studies than the previous reviews [ 35- 37].
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The cross-checking search identified five more potentially eligible studies which, on inspection of their full text, provided no quantitative data relevant to the present research question.
One study [ 26] was excluded because it was carried out on overlapping populations with another, more samples eligible study [ 27].
Seventeen clinicopathologic factors were incorporated in one or more of the eligible studies' multivariate analysis.
Using different search strategies and/or eligibility criteria for studies of benefit and harm will generate two or more diverse groups of eligible studies.
The 46 eligible studies included more than 24 000 children in 31 different countries.
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