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The mutant more efficiently metabolized malic acid as a carbon source and ammonia, histamine or phenylalanine as a nitrogen source than the wild type strain (Figure 7A).
3-HPAA is more efficiently metabolized by PGHS-2 than PGHS-1, as observed with many other arachidonoyl amides and esters.
Pollutants which are more efficiently metabolized accumulate in urine, and urinary bio-monitoring provides a suitable approach for assessing their internal exposure doses.
These drawbacks may be partly overcome with prasugrel, a new thienopyridine agent that is more efficiently metabolized to its active form and whose magnitude and consistency of platelet ADP inhibition is greater than clopidogrel [ 26– 28].
It has been proposed that this is because unsaturated fats are more efficiently metabolized into triglycerides [ 26] and that they can rescue cells from lipotoxicity by channeling saturated fats like palmitate to triglyceride stores.
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One variety boosts yields; another more efficiently metabolizes nitrogen; a third triples levels of amylose, a starch that doesn't spike blood sugar levels.
In some cases, mutations are not deleterious, or even neutral to selection, but instead may be beneficial; perhaps enabling the bearer to perform some biochemical reaction more efficiently, metabolize a new substrate, or invade a new ecological niche.
While the fundamental genetic and metabolic model remains somewhat unclear, what is clear is that we have successfully generated a strain through adaptive evolution that can more efficiently metabolize xylose and generate higher ethanol titers than the parental strain, and that this strain offers novel insights into further hypothesis-based strain improvement strategies.
Although many manufacturers switched to the use of more-efficiently metabolized NPNs such as urea, melamine use in animal feeds persisted, particularly in China, where manufacturers illegally added large amounts of melamine to a variety of products to pass industry tests, specifically the Dumas test and the Kjeldahl method.
Although most US residents are exposed, actual exposures are very low – more than 99percentt of ingested BPA is efficiently metabolized and excreted.
This interesting finding indicates that resveratrol was efficiently metabolized to dihydroresveratrol in resveratrol-injected mice.
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