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Hand, foot and mouth disease (HFMD) is a major public health concern in Asia; more efficient vaccines against HFMD are urgently required.
Current challenges include the need for improved diagnostic methods for detection of chronic and subclinical infections and for the design of more efficient vaccines.
Almost one century after the discovery of the BCG vaccine, tuberculosis remains a major cause of global mortality and morbidity, emphasizing the urgent need to design more efficient vaccines.
The generated transcriptome data can be exploited for design of new drugs, especially against multidrug-resistant (MDR) strains, development of more efficient vaccines, and identification of biomarkers for better diagnosis.
The alarming rate of emergence of new drug resistant (MDR/XDR) M. tuberculosis strains isolated from patients, in particular HIV-infected individuals, is cause for global concern, and the race for more efficient vaccines, as well as novel antibiotics targeting either the pathogen or the host, has begun [3], [10], [11].
This information will be crucial for the development and evaluation of more efficient vaccines.
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Costs will also be lowered by having a more efficient vaccine, he said, "but I can't give you a dollar figure".
In this work, we have applied RV to the M. tuberculosis proteome with the purpose of selecting new antigens that could be used in a novel and more efficient vaccine against TB.
In addition to this low efficacy, reemergence of the disease caused by the appearance of the acquired immunodeficiency syndrome (AIDS) and multidrug-resistant (MDR) strains has generated requirements for a new and more efficient vaccine against TB [ 7].
These results suggest that improvement of BCG vaccination, such as the prime-boost DNA vaccine, represents a more efficient vaccination scheme against TB.
The development of biomaterials capable of modulating DCs in situ to enhance antigen uptake and presentation has emerged as a novel method toward developing more efficient cancer vaccines.
More suggestions(15)
more costly vaccines
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com