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Clinical relevance is important for fixed and other more efficient study designs (such as group-sequential designs [ 15]).
Mandating a biopsy of metastases at study entry would ensure that the target is expressed and would allow for a more efficient study to be carried out.
Each animal in an outbred population is genetically unique, which leads to more efficient study designs compared with strain panels (Belknap 1998).
Many report musculoskeletal pain, but since the prevalence of work related musculoskeletal diagnoses are low, we need to develop more efficient study designs that may unravel questions concerning causality.
21 The enhanced risk modelling will help classify individuals into higher and lower risk groups more accurately, by using both HLA and non-HLA genetic signatures, thereby permitting a more efficient study design and analysis in the future.
Size isn't everything, however; it is equally likely that more efficient study designs of selected cohorts aimed at maximizing the power to detect association will make further significant discoveries, and at considerably lower genotyping cost than simply increasing the sample size.
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This would allow laboratory scientists to weed out weak hypotheses while focusing on the ones that have a better chance of being proven correct, and hence resulting in more efficient studies.
Some people have more efficient brains," study co-author Professor Eric Schumacher explained to Science Daily.
"This study shows that, like humans, baboons have the ability to transmit and accumulate changes over 'cultural generations' and that these incremental changes, which may differ depending on the chain, become structured and more efficient," the study's press release notes.
Any biological clue which refers to a type of PTMs can certainly help designing a more efficient proteomic study approach.
In order to elucidate and possibly exploit the function of redundant genes for oilseed rape crop improvement, it may therefore be more efficient to study the effects in one of the diploid Brassica species such as B. rapa.
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