Chronic neurological adaptations result in a more efficient sequence of recruitment of motor units, making the muscle less apt to tire from neuromuscular factors.
Consideration of whether the process can be rearranged in a more efficient sequence 5.
The recent addition of paired end sequencing to second generation sequencing, the increased read length and the predicted further increase in sequence length and tens of gigabases of useful sequence data per machine run in the near future [ 23, 26], will allow more efficient sequence assembly.
The NRC report, Mapping and Sequencing the Human Genome, sought to accommodate the scientists' concerns by formulating recommendations that genetic and physical mapping and the development of cheaper, more efficient sequencing technologies precede large-scale sequencing, and that funding be provided for the mapping and sequencing of nonhuman ("model") organisms as well.
MPS of targeted regions defined by linkage analysis is already being replaced by exome sequencing, with whole genome sequencing approaching a reality as costs fall with the advent of more efficient sequencing technologies.
Just as lessons learned from early whole-genome sequencing projects led to more efficient sequencing of related genomes in subsequent projects, we can leverage the thousands of microarray experiments performed in the yeast S. cerevisiae to direct efficient expression profiling in a related organism.
Epigenetic molecular clocks are experimentally much more efficient than sequence somatic clocks because mutation frequencies in tumor cell lines are about one per million bases [ 26] whereas multiple epigenetic errors are readily found after sequencing only a few hundred bases.
In our case, rather than redrawing all participants in a CLIA laboratory prior to running the PRGNSeq, we found it more efficient to sequence 900 existing non-CLIA samples from ∼ 6300 eligible biobanked participants at GH, and then recollect 450 participants of interest.
The emergence of next-generation sequencing technologies has enabled more efficient genome sequencing at a significantly lower cost than ever before and has provided the community with the opportunity to find genome-wide DNA polymorphisms for genetic studies.
The emergence of next-generation sequencing (NGS) technologies has enabled more efficient re-sequencing of a large number of genomes at a significantly lower cost than ever before and has provided the opportunity to survey high-throughput genotyping and large-scale genetic variation (Weigel and Mott 2009).
In heterologous (artificial polyprotein) contexts, the 2A sequence remains as a C-terminal extension of the upstream gene: potentially a consideration when using longer, albeit more efficient, F2A sequences.
