Sentence examples for more efficient reprogramming from inspiring English sources

Therefore, a greater understanding of the reprogramming process will assist identification of reprogramming roadblocks and more efficient reprogramming technologies.

This approach builds a testable model to guide the discovery of cell reprogramming recipes instead of depending on qualitative guesswork and trial and errors, and thus, will pave the road to more efficient reprogramming protocols for regenerative medicine.

This rapid induction of endogenous pluripotency genes in the majority of target cells results in a significantly more efficient reprogramming process, up to two orders of magnitude higher than standard four-factor reprogramming.

However, an intriguing observation from iPS cell derivation protocols that have compared somatic cell types of different developmental ages is that younger cell types appear to exhibit more efficient reprogramming to the iPS cell state (14, 27).

It has been reported that iPS cells acquire DNA damage and undergo p53-mediated apoptosis during reprogramming, and that p53 disruption results in more efficient reprogramming in the presence of DNA damage (Marión et al., 2009).

These results may explain why 10T1/2 nuclei show a retarded transcriptional reprogramming of pluripotent genes because their promoter and regulatory regions form bivalent domains in 10T1/2 nuclei, but the strong increase of H3K4 me3 without an H3K27 me3 increase may result in more efficient reprogramming in DmES nuclei.

By defining limiting components, it may be possible to achieve more efficient molecular reprogramming.

More studies have used the Yamanaka combination than the Thomson/Yu combination, likely because the Yamanaka factors themselves are more efficient in reprogramming.

This finding corroborates the earlier observation that Klf2 and Klf4 are far more efficient at reprogramming somatic cells into iPS cells than Klf5 [ 8].

Cells from older individuals are much harder to reprogram than those from younger ones, and it is both faster and 100-fold more efficient to reprogram keratinocytes than fibroblasts (Aasen et al., 2008).

Excitingly, they identified a special cell state known as the "privileged" cell state that is more amenable to non-stochastic and highly efficient reprogramming.