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In this scenario, miR-122 can be speculated to provide the decisive increase in translation efficiency that results in more efficient replication of HCV in liver cells compared with other cells and by that finally makes HCV a hepatotropic virus.
The genetic changes associated with more efficient replication in the intestine are also associated with increased neurovirulence, and probably also contribute to more efficient transmissibilities because of higher yields of excreted virus[47].
As a consequence of this process the virus becomes more adapted for the embryo, reflected by more efficient replication and higher pathogenicity for the embryo, with concomitant attenuation for chickens and in some cases loss of immunogenicity.
These mutations were subsequently shown to contribute to increased NA activity, resulting in more efficient replication in mammalian cells, most likely by preventing the formation of virus aggregates.
Supplementary origins and low inter-origin distance ensure faster and more efficient replication in embryonic systems, facilitating the bypass of eventual obstacles to replication progression (Woodward et al, 2006).
We speculate that the excess of these iron acquisition systems contributed greatly to the ability of both outbreak lineages of K. pneumoniae to cause systemic infections, potentially by allowing more efficient replication whilst in the bloodstream through enhanced iron chelation.
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The amount of virus produced after replication of Sabin poliovirus type 1 in K562 cells did seem to increase after the first passage, suggesting that replication of the passaged virus is more efficient than replication of the parental virus.
In that study, plasmid DNAwas replicated by sequential incubation into cytosolic and nucleoplasmic extracts, a system that bypasses the need for nuclear assembly and results in a more synchronous and more efficient plasmid replication than our more physiological, nuclear assembly-dependent replication system.
QFS uses a more efficient data replication system based on Reed-Solomon coding so that data takes up less disk space — this also reduces the overall IO required.
Thus, more efficient RNA replication could cause faster cell growth, leading to the emergence of Darwinian evolution at the cellular level.
High abundance of CHK1 in AML patient cells correlated with higher clonogenic ability and more efficient DNA replication fork progression upon cytarabine treatment.
More suggestions(15)
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