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The data show that rhGas6 treatment resulted in more efficient repair following cuprizone-induced injury.
Overall, these results suggest that compared to PBS, rhGas6 treatment resulted in more efficient repair of the corpus callosum following cuprizone toxicity.
In contrast, miR-210 promotes a more efficient repair of DSBs [ 35].
Thus, it was speculated that LNAs may stabilize the ODN/DNA interactions and result in a more efficient repair.
Classical DNA repair pathways can adapt to facilitate more efficient repair when cells are exposed to high levels of IR.
Much remains to be understood about this spontaneous repair process in order to design new therapeutic strategies promoting more efficient repair.
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The predictive role of pretreatment ERCC1 expression level might be connected with the capacity for DNA damage repair, that is, tumour cells with a more efficient DNA repair capacity can be resistant to cisplatin-based chemotherapy or radiotherapy.
The same severity of genotoxicity causes more severe DNA damage in cancer cells than in normal cells, thus eliciting cancer cell-specific killing, because normal cells have intact DNA damage response and intact DNA repair mechanism and thus can arrest proliferation for more efficient DNA repair and to avoid damage by the drug.
Isoform 2 may result in more efficient DSB repair thus promoting cancer cell survival, or isoform 1 may be critical for initiating DSB repair and cell death pathways, thus reduction in isoform 1 results in failure of cancer cells to initiate apoptosis after RT.
Therefore, since Suv39h1 downregulation was also shown to be beneficial for heterochromatin DNA repair [ 56], it is plausible that Suv39h1 knock-out in Zmpste24 mice results in slightly more efficient DNA repair and extended lifespan.
Like several other researchers receiving the grants, Dr. Rowe has done some research using adult stem cells, but is hoping that embryonic cells will be stronger and more efficient to repair the most serious wounds.
More suggestions(15)
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