As the rodent parasite P. berghei offers a simple animal model and much more efficient genetic manipulation than P. falciparum [25], [26], it may facilitate characterization of plasmodial protein export, especially since it was recently shown that a PEXEL/VTS motif allowed GFP export into the P. berghei-infected erythrocyte [27].
In doing so, it has become evident that reprogramming is exponentially more efficient, requiring less genetic manipulation, when cells isolated from developmentally immature tissues are used.
WMAD is a relational database designed to make the management of large hydrologic datasets more efficient and less prone to manipulation errors.
To increase our knowledge of gene function there is a need to develop better and more efficient tools to target gene manipulation.
More recently, an elite genotype for in vitro cellular manipulation, which showed more efficient regeneration ability than Coker lines, was identified in our laboratory [ 20].
As is evident from the results from Table 1, BDD representation and manipulation can be far more efficient on a synchronous representation as compared to the asynchronous representation.
Since genetic manipulation in P. berghei is more efficient than in P. falciparum, the data we present here suggest that evaluation of bioinformatics predictions of the P. falciparum secretome can be easily undertaken in P. berghei.
And human manipulation, intended to make larger more efficient food animals, may have unintended consequences.
However, designing a more efficient Rubisco protein is rather problematic since its structural manipulation leads frequently to an enhancement of oxygenase activity, which is responsible for photorespiratory losses.
In the future this will allow the manipulation of these pathways providing a more efficient response of legumes towards water shortage.
