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The serum levels of calcium are strictly regulated and an insufficient calcium intake is met by a more efficient intestinal absorption and renal conservation of calcium.
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The observation that the pathogen load was not substantially different between the wild-type nematode and the lin-7 mutant suggests that the enhanced survival exhibited by the lin-7 mutant is unlikely due to a more efficient restriction on intestinal bacterial growth.
The uptake data suggest that either the nano-Ag could be more efficient at crossing the intestinal barrier than the bulk Ag, or that the dissolution of the nano-Ag, either in the surrounding water or the contents of the gastrointestinal tract, is greater than the bulk Ag, allowing greater uptake of free ions.
This work clearly demonstrates that an intraperitoneal administration of CpG-ODN is more efficient in neonates than in adults to stimulate an intestinal chemokine response due to their lower IL-10 intestinal level.
Unraveling the mechanisms of nanoparticle transport across the intestinal barrier is essential for designing more efficient nanoparticles for oral administration.
As for wild-type mice, the administration of CpG-ODN by oral route to IL10KO mice is much more efficient in neonates than in adult to stimulate an intestinal chemokine response (Fig. 6B).
This hypothesis is in accordance with the observation that tumor-promoting mutations in ISCs are more efficient in generating tumors than mutations in other, more differentiated intestinal epithelial cells24,34.
Similarly, [ 24] studying bulls of different breeds, described that a more efficient and higher growth rate breed of cattle had more cells in all small intestinal segments analyzed than the less efficient and lower growth rate cattle breed.
The emergence of new protective agents of the intestinal mucosa with improved film forming efficacy, such as xyloglucan, offers new alternatives for a more efficient control of diarrheal diseases [ 3, 13].
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