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At 120 min, 5% and 10% of the total added radioactivity internalized for [111In]AT1S and [111In]AT2S, respectively, revealing a significantly more efficient internalization process for the DTrp8 analog (Figure 4B). Figure 4 Comparative internalization of [ 111 In]andS and [ 111 in]AT2S in AR4-2J cells.
As a control, the internalization of TRITC-De into Rab34 DN mutant transfected 293 cells was partially inhibited, whereas wt and CA constructs allowed more efficient internalization of De (wt 64.3%±6.0% SD, CA 60.2%±0.3% SD).
Control studies assured that the entry of TRITC-De into DN transfected 293 cells was partially inhibited (19.7%±0.20% SD), while CA transfected cells allowed more efficient internalization (39.8%±3.39% SD).
Therefore, the significantly higher antitumor activity of anti-TF-NC-6300 anti-TF-NC-6300 anti-TF-NC-6300 anti-TF-NC-6300umightistribution and thaveore efficient internalization in the tumor cells, compared with NC-6300.
Macrophages were less able to take up softer particles than the rigid ones, while hepatic carcinoma cells (HepG2) exhibited a more efficient internalization kinetics and magnitude in the case of softer hydrogel particles as compared to the stiffer, highly cross-linked particles of the same composition.
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In addition, confocal microscopy, flow cytometry and in vitro transfection analyses demonstrated more efficient cellular internalization of DTX and MMP-9 shRNA after incubation with PAG/DTX- MMP-9 shRNA micelles (PAG/DTX-shRNA) than with free drugs.
A more efficient interaction or internalization of BMJ71 bacteria thus cannot explain the survival benefit of AP1 bacteria in phagosomes.
Although neck-specific antibodies exhibited lower function-blocking ability, they were more efficient at inducing molecule internalization.
Simply speaking, there was a huge prokaryotic biomass to be harvested by predators, and few would doubt that complete internalization is more efficient then external digestion and osmotrophy.
After a 10-min pulse of transferrin, medial plane confocal optical sections illustrate that both the clone 1.E cells and neighboring GFP-FCHO1-transfected cells accumulate the ligand in perinuclear endosomes, albeit internalization is more efficient in the presence of expressed FCHO1.
Additionally, the virulent amoebae showed a more efficient system for the binding and internalization of B-holo-Lf than nonvirulent amoebae.
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