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All engineered strains exhibited a significantly higher growth rate and cell viability at 37 °C, which conferred increased thermo-tolerance and more efficient glucose conversion to ethanol.
This more efficient glucose transporting strain (green line) will rapidly out-compete the original strain for glucose, achieving a state of maximum entropy for that dish at a time significantly earlier than the genetically stable bacterial strain (blue line).
The third dish at time 0 contains the same bacterial strain as the second dish, but soon after (time denoted by green arrow), a subpopulation experiences a rare beneficial mutation in a cell membrane glucose transport gene, rendering it a more efficient glucose transporter compared with the original strain.
Thus sarcopenia due to age-related muscle atrophy could mean increased insulin sensitivity and more efficient glucose disposal [11].
We showed for the first time that STZ-induced diabetic orexin knockout mice shows a more efficient glucose handling compared to control OX−/− and C57BL/6 and STZ-treated C57BL/6 mice.
A study performed in Saccharomyces cerevisiae showed that improved ethanol tolerance translates to a more efficient glucose to ethanol conversion rate [ 32].
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This shows that the cMycCHO cell line could be considered more efficient at glucose utilisation.
The inhibition of lipolysis in lieu of the more efficient substrate glucose may result in improved inotropy, along with enhancement of other cardiovascular parameters, the summation of which is reflected in an improvement in the patient's condition.
Whereas, in some situations such as carbohydrate starvation, glucose and sucrose appear to have similar effects on gene expression [ 12], in some abiotic stress responses, such as response to anoxia [ 47], synthesis of anthocyanins [ 69], and response to PSII herbicides [ 7], sucrose treatment is more efficient than glucose treatment in providing protection mechanisms against the stress condition.
In the present study, a switch in substrate preference away from more oxygen efficient glucose oxidation, towards fatty acid oxidation with high fat feeding [ 5] may have contributed to an increase in oxygen consumption and decrease in cardiac efficiency.
Further, a repeated batch process with e.g. 100 g glucose L−1, C/N 65, would be more efficient in converting glucose to lipid if a rate of 0.33 g lipid L−1 h−1 would be sustained without the lag phase.
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