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The significance of this interaction was totally unclear despite the authors' speculation that a comprehensive binding of p53 to different Nucleotide Excision Repair (NER) proteins, including XPB and XPD, might potentiate the cellular response to DNA damage and result in a more efficient DNA repair.
The predictive role of pretreatment ERCC1 expression level might be connected with the capacity for DNA damage repair, that is, tumour cells with a more efficient DNA repair capacity can be resistant to cisplatin-based chemotherapy or radiotherapy.
The same severity of genotoxicity causes more severe DNA damage in cancer cells than in normal cells, thus eliciting cancer cell-specific killing, because normal cells have intact DNA damage response and intact DNA repair mechanism and thus can arrest proliferation for more efficient DNA repair and to avoid damage by the drug.
The more efficient DNA repair capacity of the parous rat mammary gland is demonstrated by the induction of unscheduled DNA synthesis and a removal of DMBA-DNA adducts.
Since DNA-PKc is a catalytic subunit, these data support the hypothesis that TICs in fact have more efficient DNA repair capabilities.
Human tumor cell lines selected for resistance to cisplatin showed more efficient DNA repair and increased expression of XPE binding factor.
Similar(28)
Moreover, DNA polymerase λ is more efficient than DNA polymerase β to fill this oxidized single-nucleotide gap.
In fact, this new low-current, low-voltage and long-duration pulse procedure, has been proved recently to be safer and more efficient in DNA electrodelivery [4], [33].
volcanii is more efficient with DNA from E. coli strains with dam− mutations (which make the cell unable to methylate at GATC sites) than from dam+ strains.
The simplified version is more efficient for DNA sequences with a very small alphabet.
It is possible that those oocytes which inherently are more efficient in DNA repair are more likely to be resistant to chemotherapy-induced DSBs and cell death.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com