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Therefore, we hypothesize that SLITs maintain vessel integrity via SLIT2/ROBO1 ROBO4 interaction and because of more efficient binding of SLIT2 with ROBO1, it preferentially binds to ROBO1, leading to the deficiency of free SLIT2.
Purified PLG bound efficiently to the spore surface, while plasmin showed more efficient binding in the NHS (Figure 2A), suggesting less existence of PLG in the NHS.
In addition, by increasing the nanotube's diameter – decreasing its curvature, more efficient binding energies of hydrogen can be achieved.
Br-Mac-12 has a more efficient binding capacity with DNA than the corresponding DTAB without the fluorophore.
Although various oligonucleotide backbone modifications have been invented for more efficient binding to complementary RNA [23, 24], these modifications require substitution of multiple nucleotides.
The CoMFA generated steric map indicated that the PIM-1-binding site was sterically hindered, leading to more efficient binding of planar molecules over (R) or (S) compounds.
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We also confirmed that the GTP-bound form of ARF1 was more efficient in binding to liposomes and in recruiting coatomer to this membrane (Fig. 2A).
As indicated in Table 1, adduct formation of trioxacarcin A (2) with oligonucleotide 4a is about five times more efficient than binding to DNA 4b.
If ECM remodeling and GF signaling is entirely responsible for human to rat differences (Hyp 2), then GF production in humans should be slower than rats and human ECM should be more efficient in binding GF than rat ECM.
This increase in activity appears to be attributable to both more efficient DNA binding and a faster rate of translocation when these spacing enzymes are able to engage linker DNA.
T3S translocation is dependent on Pa contact with eukaryotic cells, but differences in T3S translocation did not relate to more efficient Pa binding to MTLn3 cells, as an approximately equal number of Pa (3.5±1.3 and 3.6±1.2) bound per MTLn3 and MTC cell, respectively.
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