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The identification of mutant p53-reactivating small molecules such as PRIMA-1 opens possibilities for the development of more efficient anticancer drugs.
This distinct responsiveness is a crucial parameter to be evaluated aiming at the implementation of more efficient anticancer therapeutic strategies.
The overall results indicate MKK3 as a novel promising molecular target for the development of more efficient anticancer treatments in both wtp53- and mutp53-carrying tumors.
Our results could allow the utilization of a more targeted therapy and the development of more efficient anticancer therapies for ovarian cancer.
In a nutshell, the multitherapy SQ-gem/isoCA-4 nanoassemblies displayed the more efficient anticancer pharmacological activity with almost complete suppression of tumor growth and absence of toxicity related to weight loss.
There is growing evidence indicating that loading a broad spectrum of antigens rather than single antigens onto DCs potentially may give rise to more efficient anticancer immune responses (Nencioni et al, 2003; Kalady et al, 2004).
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As Nutlin and Hsp90 inhibitors are currently undergoing separate clinical trials, our results provide a molecular rationale for a more efficient Nutlin-based anticancer therapy by concomitantly targeting an essential anti-p53 directed cofactor.
More effective anticancer therapeutic strategies, many of which are based on functional genomics.
A more effective anticancer therapy is required.
After reaching phase III, there was a 55% probability of a successful marketing approval application, supporting the need for more efficient, effective approaches to anticancer drug development.
GNOLs accumulated into tumor tissues by the EPR effect; with the NIR irradiation, the gold nanoshells absorbed the light and converted it to hyperthermia, further inducing more OA released rapidly from the GNOLs to realize the most efficient anticancer effect.
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more pronounced anticancer
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com