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Namely, whether continual desensitization of TRPA1 with desensitizing agonists would provide more efficacy or better tolerability than a standard antagonist.
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The women who perceived more self-efficacy (OR = 1.08) and fewer barriers (OR = 0.70) were more likely to perform BSE.
Two analysis sets were defined: the safety analysis set, consisting of all patients who received one or more doses of the investigational product, and the full analysis set, consisting of all randomized patients who received one or more doses of the investigational product and who had a nonmissing baseline and one or more postbaseline efficacy value for one or more efficacy variable.
67 The review by Hirsch et al identified 32 studies that found a statistically significant association between histology and one or more efficacy endpoints.
Thus, the individual trials demonstrate a trend or even a significant difference in favor of the third-generation aromatase inhibitors in one or more efficacy end points; in addition, the aromatase inhibitors were shown to be associated with improved tolerability versus comparator endocrine therapy in these randomized trials.
Almost four out of five headache sufferers reported that they cared for more efficacy than for the safety or route of administration of the symptomatic or preventive treatments they were taking.
The intravenous route, for example, shows more efficacy when the drug is linked to a carrier system like polymeric depots, liposomes or lipid carriers.
Auto-continuous positive airway pressure (CPAP) has been reported to have no more efficacy than constant CPAP in unselected patients with sleep apnea hypopnea syndrome (SAHS).
This stability may lead to more efficacy and/or more side effects.
Antimalarial drugs are losing more and more efficacy against the deadliest agent, Plasmodium falciparum.
MINO had more efficacy than NAC in limiting injury following moderate CCI.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com