The periodic nature of RA signaling may be an important consideration for the more efficacious use of retinoids, for example in conjunction with targeting coregulators like RIP140.
For these reasons we believe that a quantitative and qualitative assessment of the similarities and differences between the cell surface of primary tumors and related cell lines is of outstanding importance for a more efficacious use of the cell lines as an in-vitro cancer model.
These advances have been attributed to more efficacious use of antileukaemic agents, intensification of treatment when appropriate, identification of prognostic factors for risk stratification, and improvements in supportive care (Ravindranath et al, 2005; Pui and Evans, 2006).
It is therefore possible that the more efficacious regimens used in the Ditrame Plus study would have led to reduced transmission in the early postnatal period.
These observations suggest that use of antibodies with multiple specificities for IL-6 may be more efficacious than use of a single mAb.
The aim of the study was to evaluate the impact of prospective review of significant drug-drug interactions (DDIs) occurring in medical intensive care unit (MICU) patients by the critical care pharmacist participating in patient care rounds on improvement of safer and more efficacious medication use.
The Ministry of Health has started price negotiations with the drug manufacturer while also promoting more efficacious drug use through various measures [ 20].
Therefore, one may conclude that daptomycin might be a safer and more efficacious drug to use, in comparison with other comparator drugs in the matters of microbiological success, treatment-related AEs, discontinuation or death.
Evidence pointing towards a more efficacious model of care using a biopsychosocial approach for LBP management highlights the need to understand the pain-related beliefs of patients and those who treat them.
As of now, perioperative MIBC clinical research is mainly focused on selecting a more efficacious cisplatin-based regimen using head-to-head trials with a limited number of studies addressing regimens for cisplatin-ineligible patients.
