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Thus, understanding the role of PPAR γ in each cell type involved in the pathogenesis of IBD is critical for the informed development of novel, safer and more efficacious therapeutic and prophylactic agents against IBD.
The ultimate objective of this study will be to translate these findings into more efficacious therapeutic GCs.
Thus, NAD(P H generation may be a more efficacious therapeutic target upstream of GSH and ROS.
Thus, B cell-modulating drugs might yet be a safer and more efficacious therapeutic option for such patients.
Therefore, revisiting riluzole therapy by inhibiting pharmacoresistance could improve quality of life of ALS patients until a more efficacious therapeutic strategy is identified.
Safer and more efficacious therapeutic options are urgently needed, thus warranting the evaluation of innovative therapeutic strategies in clinically relevant models of high-risk neuroblastoma.
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Ideally, the next generation of treatments for nosocomial and community-acquired infections, including those caused by Candida spp, Aspergillus spp, Cryptococcus spp and Fusarium spp, will be more efficacious, with higher therapeutic indices and broader activity spectra than existing antifungal drug classes.
The characterization of novel angiogenic factors and potential targets involved in the induction of tumor vascularization could contribute to the development of more efficacious anti-angiogenic therapeutic approaches.
In this way, we may eventually develop more efficacious, mechanism-driven therapeutic strategies to overcome resistance.
In a broader context, there is a growing interest in dietary HDACi, in particular butyrate because its impact on epigenetic mechanisms will lead to more specific and efficacious therapeutic strategies in the prevention and treatment of different diseases.
There is a growing interest in butyrate because its impact on epigenetic mechanisms will lead to more specific and efficacious therapeutic strategies for the prevention and treatment of different diseases ranging from genetic/metabolic conditions to neurological degenerative disorders.
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