In this way, we may eventually develop more efficacious, mechanism-driven therapeutic strategies to overcome resistance.
In this chapter, we will cover some of these strategies for knowledge-based rational design for GPCRs and will discuss the main hurdles which they may need to overcome to yield novel, safer and more efficacious drugs possessing polished mechanisms of action.
This requires a more efficacious system based on more sophisticated mechanisms for full accomplishment of both the biological and the psychophysical requirements for detection of, and reaction to, physical menaces.
As with anti-Aβ immunotherapies, it is likely that a better understanding of the mechanism will ultimately result in more efficacious and safer immunotherapy.
The developed mineralized tumor models may help to reveal the underlying cellular and molecular mechanisms that may ultimately enable more efficacious therapy of patients with advanced breast cancer.
We hypothesize that for patients with severe hypotension, lower doses of multiple vasopressors with differing mechanisms of action may be more efficacious and less toxic than high doses of one type of vasopressor (that is, catecholamines).
However, since the spectrum of activity of Mek inhibitors is predicted to be broader, many efforts are being carried out to develop more efficacious, less toxic substances, and to better understand their mechanism of action.
Compared with diabetes patients, adolescents in our overall sample used most strategies less often, but perceived most strategies to be more efficacious which might be understood as a psychologically protective mechanism.
Therefore, there is a pressing need to understand the causes and mechanisms of OA pain so that more efficacious targets can be identified to help alleviate these debilitating symptoms.
Thus, it is important to disclose the mechanism of persistent cough and to develop more efficacious treatment.
This personalized, adaptive mechanical breath may prove more efficacious at treating and preventing ARDS than the current standard of care.
