Sentence examples for more efficacious less from inspiring English sources

The discovery of additional Brucella virulence factors thus may facilitate the development of a more efficacious, less reactogenic, acellular product that may either be used as a stand-alone vaccine or used to augment primary immunization with the existing live, attenuated platform.

However, since the spectrum of activity of Mek inhibitors is predicted to be broader, many efforts are being carried out to develop more efficacious, less toxic substances, and to better understand their mechanism of action.

If the result of the modelling indicated that one of the therapeutic options was more efficacious (less IFI or greater number of LYS) and, in turn, had a lower total cost compared to the other option, this would establish therapeutic dominance.

A biobetter form of one of these molecules would involve taking the originator molecule and making specific alterations in it to improve its parameters and thereby make it a more efficacious, less frequently dosed, better targeted, and/or better tolerated drug.

The presence of this protein appears to be an important prognostic factor and, combined with an age-adjusted International Prognostic Index, could allow researchers to design more specific clinical trials aimed at finding new, more efficacious and less toxic treatments.

A series of novel conjugates of brefeldin A (11a−c, 12a−c and 13a−c) were obtained by introducing a variety of nitrogen mustards at 4-OH or 7-OH position to explore more efficacious and less toxic antitumor agents.

LC resulted a dominant strategy (more efficacious and less costly) compared to CB. One-way sensitivity analysis results confirmed model and parameters robustness as LC continued being a dominant strategy in all the analysis performed (Table 4), apart from the inclusion of unrelated future dialysis costs, which provided an ICER of €45,554 per QALY gained.

Nonetheless, there remains a dire need for more efficacious and less toxic therapies.

There is a need, therefore, for safer, more efficacious and less complex stroke prevention therapy.

Our results showed that the EC-DT regimen was more efficacious and less toxic than the EC-DL schedule.

WP1066 administrated orally is more efficacious and less toxic than WP1066 injected intraperitonealy or intravenously (Kong et al, 2008).