CONCLUSIONS: Combined treatment for advanced head and neck cancer is more efficacious and not more toxic than hyperfractionated irradiation alone.
Since nanosized materials often exhibit unique properties that may offer significant advantage for biomedical applications (Jain 2008; Martin and Kohli 2003), it is sensible to investigate if nano-alum will be more efficacious in enhancing anticancer immune response than conventional alum.
Therefore, stimulating hERG1 channel activity could be preparatory for more efficacious effects of an activated immune system and/or antiproliferative drugs.
Although the mechanistic underpinnings of immune priming are not well understood (but see [ 6, 7]), what is clear is that the innate immune response is more efficacious after a preliminary encounter [ 8].
However, it remains to be determined why targeting these immune checkpoint inhibitors is more efficacious in some solid tumor malignancies versus others and in some, but not all, patients with the same malignancy.
4, 5, 6 These results suggest that sequential cancer therapy involving PPV followed by immune checkpoint inhibitors could be more efficacious than the monotherapy.
Thus, it is conceivable that the combination of HD IL-2, to induce T-cell expansion, and PD-1 blockade, to eliminate tumor-induced immune suppression, might prove equally or more efficacious in select patients.
Therefore, alternative vaccine formulations, adjuvantation and routes of delivery are being investigated to create a more efficacious vaccine that would induce long-lived mucosal and systemic immune responses with broader cross-protection.
For example, the price of medication impacts on its efficacy, with more expensive medications being more efficacious than cheaper ones.
Using machine learning as opposed to ODE-based methods will reduce the computational complexity of the system and allow us to gain a deeper understanding of the complex interplay between the molecules, cells and tissues of the immune system to advance the development of safer and more efficacious therapeutics.
