A better understanding of how these cellular components work together to combat environmental stresses could lead to new strategies for more efficacious dosing of existing antibacterial agents as well as the development of novel therapeutics.
However, the common use of more efficacious high doses of CQ in Guinea-Bissau probably turns pfcrt 76T into a marker of tolerance.
Liposomal encapsulation also significantly reduced mitoxantrone toxicity, allowing administration of higher, more efficacious drug doses.
The thrice-weekly i.v. infusion schedule was chosen because in murine studies frequent dosing was more efficacious than intermittent dosing with little difference between dosing daily and three times per week.
First, when larger doses are not much more efficacious than smaller doses, the smaller doses are likely to be more cost-effective.
The rationale for this point is based on the results of several phase I and II clinical trials with NGR-hTNF showing that low doses of the drug, for example, 0.8 μg m−2 (Gregorc et al, 2010a) (i.e., 18 ng per kg), are more efficacious than higher doses tested in phase I dose escalation studies (van Laarhoven et al, 2010; Gregorc et al, 2010a; Zucali et al, 2013).
In tests with various human cancer xenograft models, capecitabine was more efficacious at wider dose ranges than either 5-FU or 5′-DFUR and was significantly less toxic to the intestinal tract than the others in monkeys.
Metoclopramide may well be more efficacious at a dose of 20 mg, but currently there is no evidence to support this in the absence of an adequately powered and randomized study.
Daily doses appear to be safer and more efficacious than large doses administered once or twice a year.
Evaluation of results confirmed that a single intraperitoneal injection of the phage dose was more efficacious than the multiple doses of imipenem.
